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Article

Fission yeast Taz1 and RPA are synergistically required to prevent rapid telomere loss.

Molecular biology of the cell - 1 Jun 2007

Kibe Tatsuya, Ono Yuuki, Sato Koichiro, Ueno Masaru

Abstract excerpt

The telomere complex must allow nucleases and helicases to process chromosome ends to make them substrates for telomerase, while preventing these same activities from disrupting chromosome end-protection. Replication protein A (RPA) binds to single-stranded DNA and is required for DNA replication, recombination, repair, and telomere maintenance. In fission yeast, the telomere binding protein Taz1 protects...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17429064
DOI: 10.1091/mbc.e06-12-1084
PMCID: PMC1877100

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Fission yeast Taz1 and RPA are synergistically required to prevent rapid telomere loss.PMID 17429064Read ↗

Taz1, Rap1 and Rif1 act both interdependently and independently to maintain telomeres.Semantic proximity Read ↗

Fission yeast RPA–TERT–Tpz1 <sup>TPP1</sup> complex promotes telomere extension and suppresses telomere recombinationSemantic proximity Read ↗

Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length.Semantic proximity Read ↗

The telomere protein Taz1 is required to prevent and repair genomic DNA breaks.Semantic proximity Read ↗

Distinct functions of POT1 at telomeres.Semantic proximity Read ↗

RPA prevents G-rich structure formation at lagging-strand telomeres to allow maintenance of chromosome ends.Semantic proximity Read ↗

A double mutant between fission yeast telomerase and RecQ helicase is sensitive to thiabendazole, an anti-microtubule drug.Semantic proximity Read ↗

Sumoylation of RecQ helicase controls the fate of dysfunctional telomeres.Semantic proximity Read ↗

Fission yeast Pot1 and RecQ helicase are required for efficient chromosome segregation.Semantic proximity Read ↗

Fission yeast RecQ helicase Rqh1 is required for the maintenance of circular chromosomes.Semantic proximity Read ↗

Rad51-dependent aberrant chromosome structures at telomeres and ribosomal DNA activate the spindle assembly checkpoint.Semantic proximity Read ↗

A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms.Semantic proximity Read ↗

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