Article

Human Replication Protein A complex is a Telomerase Processivity Factor Essential for Telomere Maintenance

2024-08-17

Abstract excerpt

Telomerase is crucial for maintaining telomere length and safeguarding genome stability. In this study, we identified Replication Protein A (RPA) as a novel telomerase processivity factor, functioning alongside the telomerase recruitment factor TPP1-POT1. AlphaFold2 predictions revealed that RPA and TPP1 interact with telomerase at distinct binding sites. Using separation-of-function mutants, we discovered that RP...

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Literature Corpus work: c7724fb9-b5dd-5569-8ffb-a82684b89e70
DOI: 10.1101/2024.08.16.608355

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