Article

The structurally conserved TELR region on shelterin protein TPP1 is essential for telomerase processivity but not recruitment

2020-12-07

Abstract excerpt

In addition to mediating telomerase recruitment, shelterin protein TPP1 also stimulates telomerase processivity. Assessing the in vivo significance of the latter role of TPP1 has been difficult, as TPP1 mutations that perturb telomerase function tend to abolish both telomerase recruitment and processivity. We sought to separate the two activities of TPP1 in regulating telomerase by considering a structure-guided...

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Literature Corpus work: 82e8eac8-1678-5e01-8483-47dabbcbdf89
DOI: 10.1101/2020.12.07.412684

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