Article

Methyl-CODEC enables simultaneous methylation and duplex sequencing

2024-12-23

Abstract excerpt

DNA mutations and methylation often contribute to disease development in a synergistic manner. While duplex sequencing is the most accurate method for detecting DNA mutations, it typically lacks the ability to simultaneously assess methylation or requires many reads. Here, we developed Methyl-CODEC to enable simultaneous methylation sequencing and duplex sequencing using single read pairs. To achieve this, Methyl-...

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Literature Corpus work: 6860ed36-6393-5678-8031-e35d8a04c840
DOI: 10.1101/2024.12.23.630102

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