Article
A new approach to decode DNA methylome and genomic variants simultaneously from double strand bisulfite sequencing.
Briefings in bioinformatics - 5 Nov 2021
Liang Jialong, Zhang Kun, Yang Jie, Li Xianfeng, Li Qinglan, Wang Yan, Cai Wanshi, Teng Huajing, Sun Zhongsheng
Abstract excerpt
Genetic and epigenetic contributions to various diseases and biological processes have been well-recognized. However, simultaneous identification of single-nucleotide variants (SNVs) and DNA methylation levels from traditional bisulfite sequencing data is still challenging. Here, we develop double strand bisulfite sequencing (DSBS) for genome-wide accurate identification of SNVs and DNA methylation simultaneously...
Topics
- Computational Biology
- CpG Islands
- DNA Methylation
- Epigenesis, Genetic
- Epigenomics
- Genetic Background
- Genetics, Population
- Genomics
- Polymorphism, Single Nucleotide
- Sequence Analysis, DNA