Article

Benchmarking of duplex sequencing approaches to reveal somatic mutation landscapes

2025-12-15

Abstract excerpt

Detecting somatic mutations in normal tissues is challenging due to sequencing errors and the low allele fractions of post-zygotic variants. Duplex sequencing greatly reduces errors and can detect mutations at any allele fraction, but systematic, cross-platform comparisons are lacking. We present a comprehensive benchmarking of six duplex sequencing technologies used by the SMaHT Network: CODEC, CompDuplex-seq, Hi...

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Literature Corpus work: 056ec887-e0db-550a-86b7-3b0338ab1fc2
DOI: 10.64898/2025.12.12.692823

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