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Article

Methyl-SNP-seq reveals dual readouts of methylome and variome at molecule resolution while enabling target enrichment.

Genome research - 1 Jan 2000

Yan Bo, Wang Duan, Vaisvila Romualdas, Sun Zhiyi, Ettwiller Laurence

Abstract excerpt

Covalent modifications of genomic DNA are crucial for most organisms to survive. Amplicon-based high-throughput sequencing technologies erase all DNA modifications to retain only sequence information for the four canonical nucleobases, necessitating specialized technologies for ascertaining epigenetic information. To also capture base modification information, we developed Methyl-SNP-seq, a technology that takes...

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PMID: 36332968
DOI: 10.1101/gr.277080.122
PMCID: PMC9808626

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