Article
DNA mismatch and damage patterns revealed by single-molecule sequencing.
Nature - 1 Jun 2024
Liu Mei Hong, Costa Benjamin M, Bianchini Emilia C, Choi Una, Bandler Rachel C, Lassen Emilie, Grońska-Pęski Marta, Schwing Adam, Murphy Zachary R, Rosenkjær Daniel, Picciotto Shany, Bianchi Vanessa, Stengs Lucie, Edwards Melissa, Nunes Nuno Miguel, Loh Caitlin A, Truong Tina K, Brand Randall E, Pastinen Tomi, Wagner J Richard, Skytte Anne-Bine, Tabori Uri, Shoag Jonathan E, Evrony Gilad D
Abstract excerpt
Mutations accumulate in the genome of every cell of the body throughout life, causing cancer and other diseases1,2. Most mutations begin as nucleotide mismatches or damage in one of the two strands of the DNA before becoming double-strand mutations if unrepaired or misrepaired3,4. However, current DNA-sequencing technologies cannot accurately resolve these initial single-strand events. Here we develop a...
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