Article

Single-strand mismatch and damage patterns revealed by single-molecule DNA sequencing

2023-02-19

Abstract excerpt

Mutations accumulate in the genome of every cell of the body throughout life, causing cancer and other genetic diseases 1-4 . Almost all of these mosaic mutations begin as nucleotide mismatches or damage in only one of the two strands of the DNA prior to becoming double-strand mutations if unrepaired or misrepaired 5 . However, current DNA sequencing technologies cannot resolve these initial single-strand events...

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Literature Corpus work: 0a4c667b-d4f5-56f6-ba0b-b227427e1d5a
DOI: 10.1101/2023.02.19.526140

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