Article
A DNA alteration and methylation co-detection method for clinical purpose.
EMBO molecular medicine - 1 Jul 2025
Yu Jiyan, Yang Chunhe, Zhu Xintao, Wang Zhankun, Xu Boping, Cai Ye, Zhao Jingbo, Guo Ruijian, Yuan Wuzhou, Wang Jianqing, Dong Bohao, Zheng Frank Ron, Yang Shuang
Abstract excerpt
Traditional approaches for capturing genomic alterations and DNA methylation require separate assays, complicating clinical workflows and limiting sample utilization, particularly with low-input materials like cell-free DNA. To address these challenges, we introduce a streamlined approach combining mutation and methylation profiling via mutation-protective strand synthesis with modified deoxycytidine...
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