Article

CODEC enables ‘single duplex’ sequencing

2021-06-12

Abstract excerpt

Detecting mutations as rare as a single molecule is crucial in many fields such as cancer diagnostics and aging research but remains challenging. Third generation sequencers can read a double-stranded DNA molecule (a ‘single duplex’) in whole to identify true mutations on both strands apart from false mutations on either strand but with limited accuracy and throughput. Although next generation sequencing (NGS) can...

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Literature Corpus work: c656ac98-ab34-5854-9b65-5fabbcce5ba7
DOI: 10.1101/2021.06.11.448110

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