Article

Physical principles of phase-separation action on chromatin looping associated to pathogenic gene activation

2025-05-23

Abstract excerpt

Phase-separation of chimeric proteins resulting from genetic mutations has been shown to trigger aberrant chromatin looping, contributing to disease development, including cancer. However, the physical mechanisms regulating these processes are not yet fully understood. In this study, we employ polymer physics models of chromatin and numerical simulations to investigate the relationship between phase-separation of...

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Literature Corpus work: 667b89a3-91a1-5d70-b851-a6b5a8be1fad
DOI: 10.1101/2025.05.20.654944

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