Article

Investigating the Context-Dependent Phase Separation of Human HOX Transcription Factors

2025-01-09

Abstract excerpt

Homeobox (HOX) transcription factors are essential for gene expression during embryonic development and hematopoiesis, and their dysregulation is potentially linked to several types of cancer. Recently, liquid-liquid phase separation (LLPS) has been proposed as a key mechanism in various physiological processes. Using computational tools and molecular dynamics (MD) simulations, we found that the human HOX transcri...

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Literature Corpus work: bb05efa5-7583-5973-a0a0-e4cda599e1d1
DOI: 10.22541/au.173640022.23170329/v1

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