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Article

Physical mechanisms of chromatin spatial organization.

The FEBS journal - 1 Mar 2022

Chiariello Andrea M, Bianco Simona, Esposito Andrea, Fiorillo Luca, Conte Mattia, Irani Ehsan, Musella Francesco, Abraham Alex, Prisco Antonella, Nicodemi Mario

Abstract excerpt

In higher eukaryotes, chromosomes have a complex three-dimensional (3D) conformation in the cell nucleus serving vital functional purposes, yet their folding principles remain poorly understood at the single-molecule level. Here, we summarize recent approaches from polymer physics to comprehend the physical mechanisms underlying chromatin architecture. In particular, we focus on two models that have been...

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PMID: 33583147
DOI: 10.1111/febs.15762

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