Article

Modified histone peptides uniquely tune the material properties of HP1α condensates

2024-02-09

Abstract excerpt

Biomolecular condensates have emerged as a powerful new paradigm in cell biology with broad implications to human health and disease, particularly in the nucleus where phase separation is thought to underly elements of chromatin organization and regulation. Specifically, it has been recently reported that phase separation of heterochromatin protein 1alpha (HP1α) with DNA contributes to the formation of condensed c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9e55a7be-341e-5cc4-a80e-e278e927ddd0
DOI: 10.1101/2024.02.07.579285

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Modified histone peptides uniquely tune the material properties of HP1α condensatesDOI 10.1101/2024.02.07.579285Read

The role of electrostatic interactions in the phase separation of HP1α and its protein binding partnersSemantic proximity Read

Interplay between charge distribution and DNA in shaping HP1 paralog phase separation and localizationSemantic proximity Read

Phosphoserine clusters as metal ion sensors for protein phase separationSemantic proximity Read

May the force be with you: Nuclear condensates function beyond transcription control: Potential nongenetic functions of nuclear condensates in physiological and pathological conditions.Semantic proximity Read

Condensate formation of the human RNA-binding protein SMAUG1 is controlled by its intrinsically disordered regions and interactions with 14-3-3 proteinsSemantic proximity Read

Structural mechanism of HP1α-dependent transcriptional repression and chromatin compactionSemantic proximity Read

In vitro reconstitution of heterochromatin compartments reveals the spontaneous formation of tunable liquid-liquid interfaces.Semantic proximity Read

Interrogation of the Dynamic Properties of Higher-Order Heterochromatin Using CRISPR/dCas9Semantic proximity Read

A Physics-based Model Reveals Mechanisms of Epigenetic MemorySemantic proximity Read

Physical principles of phase-separation action on chromatin looping associated to pathogenic gene activationSemantic proximity Read

53BP1 regulates heterochromatin through liquid phase separation.Semantic proximity Read

A Rahman Syndrome mutation in histone H1.4 disrupts chromatin compaction and phase separation.Semantic proximity Read