Article

Micelle-like clusters in phase-separated Nanog condensates: A molecular simulation study

2023-05-20

Abstract excerpt

The phase separation model for transcription suggests that transcription factors (TFs), coactivators, and RNA polymerases form biomolecular condensates around active gene loci and regulate transcription. However, the structural details of condensates remain elusive. In this study, for Nanog, a master TF in mammalian embryonic stem cells known to form protein condensates in vitro , we examined protein structures i...

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Literature Corpus work: 410666a8-1f9c-50e5-928d-2e9e0afa81ec
DOI: 10.1101/2023.05.18.541260

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