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A Polymer Physics Model to Dissect Genome Organization in Healthy and Pathological Phenotypes.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2022

Conte Mattia, Fiorillo Luca, Bianco Simona, Chiariello Andrea M, Esposito Andrea, Musella Francesco, Flora Francesco, Abraham Alex, Nicodemi Mario

Abstract excerpt

Novel technologies revealed a nontrivial spatial organization of the chromosomes within the cell nucleus, which includes different levels of compartmentalization and architectural patterns. Notably, such complex three-dimensional structure plays a crucial role in vital biological functions and its alterations can produce extensive rewiring of genomic regulatory regions, thus leading to gene misexpression and...

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PMID: 34415543
DOI: 10.1007/978-1-0716-1390-0_16

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