Article

Phase-separating fusion proteins drive cancer by dysregulating transcription through ectopic condensates

2023-09-21

Abstract excerpt

Numerous cellular processes rely on biomolecular condensates formed through liquid-liquid phase separation (LLPS), thus, perturbations of LLPS underlie various diseases. We found that proteins initiating LLPS are frequently implicated in somatic cancers, even surpassing their involvement in neurodegeneration. Cancer-associated LLPS scaffolds are connected to all cancer hallmarks and tend to be oncogenes with domin...

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Identifiers and source

Literature Corpus work: eea85930-0027-539a-a80e-143cd47d2b97
DOI: 10.1101/2023.09.20.558425

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