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Article

Distinct roles of hnRNPH1 low-complexity domains in splicing and transcription

6 Dec 2021

Abstract excerpt

Heterogeneous nuclear ribonucleoproteins (hnRNPs) represent a large family of RNA-binding proteins that control key events in RNA biogenesis under both normal and diseased cellular conditions. The low-complexity (LC) domain of hnRNPs can become liquid-like droplets or reversible amyloid-like polymers by phase separation. Yet, whether phase separation of the LC domains contributes to physiological functions of...

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PMID: 34873036
DOI: 10.1073/pnas.2109668118

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