Article

Structure of a Rpd3/HDAC holoenzyme complex bound to the nucleosome

2023-03-16

Abstract excerpt

<title>Abstract</title> <p>The Sin3/HDAC complexes are highly conserved from yeast to humans and function by deacetylating histones, condensing chromatin, and modulating gene expression. Despite the continued analysis of HDAC inhibitors in clinical trials, our mechanistic understanding of the HDAC activity is hindered by the lack of a high-resolution structure of complexes from this family. Here we report the cry...

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Literature Corpus work: 6673d701-68ee-588c-a681-150f7d952261
DOI: 10.21203/rs.3.rs-2667786/v1

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