Article

Visualization of PRC2-Dinucleosome Interactions Leading to Epigenetic Repression

2018-01-08

Abstract excerpt

Epigenetic regulation is mediated by protein complexes that couple recognition of chromatin marks to activity or recruitment of chromatin-modifying enzymes. Polycomb repressive complex 2 (PRC2), a gene silencer that methylates lysine 27 of histone H3, is stimulated upon recognition of its own catalytic product, and has been shown to be more active on dinucleosomes than H3 tails or single nucleosomes. These propert...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a8855824-f3df-551d-a442-118c442cfad8
DOI: 10.1101/245134

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Visualization of PRC2-Dinucleosome Interactions Leading to Epigenetic RepressionDOI 10.1101/245134Read

Structural basis for PRC2 decoding of active histone methylation marks H3K36me2/3.Semantic proximity Read

Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction.Semantic proximity Read

Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases.Semantic proximity Read

Single-molecule and in silico dissection of the interaction between Polycomb repressive complex 2 and chromatin.Semantic proximity Read

Molecular architecture of heterochromatin at the nuclear periphery of primary human cellsSemantic proximity Read

Polycomb-mediated Genome Architecture Enables Long-range Spreading of H3K27 methylationSemantic proximity Read

PHF19 drives PRC2 sub-nuclear compartmentalization to promote motility in TNBC cellsSemantic proximity Read

The structural basis for RNA slicing by human Argonaute2Semantic proximity Read

Cryo-EM structure of the human MLL1 core complex bound to the nucleosome.Semantic proximity Read

Cryo-EM structure of the human Mixed Lineage Leukemia-1 complex bound to the nucleosomeSemantic proximity Read

OpenNucleome for high resolution nuclear structural and dynamical modelingSemantic proximity Read

Structure of a Rpd3/HDAC holoenzyme complex bound to the nucleosomeSemantic proximity Read