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Article

Combined action of PHD and chromo domains directs the Rpd3S HDAC to transcribed chromatin.

Science (New York, N.Y.) - 18 May 2007

Li Bing, Gogol Madelaine, Carey Mike, Lee Daeyoup, Seidel Chris, Workman Jerry L

Abstract excerpt

Nucleosomes must be deacetylated behind elongating RNA polymerase II to prevent cryptic initiation of transcription within the coding region. RNA polymerase II signals for deacetylation through the methylation of histone H3 lysine 36 (H3K36), which provides the recruitment signal for the Rpd3S histone deacetylase complex (HDAC). The recognition of methyl H3K36 by Rpd3S requires the chromodomain of its Eaf3...

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Source

Identifiers

PMID: 17510366
DOI: 10.1126/science.1139004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Combined action of PHD and chromo domains directs the Rpd3S HDAC to transcribed chromatin.PMID 17510366Read ↗

Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex.Semantic proximity Read ↗

Histone H3 lysine 36 dimethylation (H3K36me2) is sufficient to recruit the Rpd3s histone deacetylase complex and to repress spurious transcription.Semantic proximity Read ↗

Structure of a Rpd3/HDAC holoenzyme complex bound to the nucleosomeSemantic proximity Read ↗

DSIF and RNA polymerase II CTD phosphorylation coordinate the recruitment of Rpd3S to actively transcribed genes.Semantic proximity Read ↗

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Set2 methylation of histone H3 lysine 36 suppresses histone exchange on transcribed genes.Semantic proximity Read ↗

Demethylation of histone H3K36 and H3K9 by Rph1: a vestige of an H3K9 methylation system in Saccharomyces cerevisiae?Semantic proximity Read ↗

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Different genetic functions for the Rpd3(L) and Rpd3(S) complexes suggest competition between NuA4 and Rpd3(S).Semantic proximity Read ↗

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