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Article

The FACT histone chaperone guides histone H4 into its nucleosomal conformation in Saccharomyces cerevisiae.

Genetics - 1 Sept 2013

McCullough Laura, Poe Bryan, Connell Zaily, Xin Hua, Formosa Tim

Abstract excerpt

The pob3-Q308K mutation alters the small subunit of the Saccharomyces cerevisiae histone/nucleosome chaperone Facilitates Chromatin Transactions (FACT), causing defects in both transcription and DNA replication. We describe histone mutations that suppress some of these defects, providing new insight into the mechanism of FACT activity in vivo. FACT is primarily known for its ability to promote reorganization of...

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Identifiers

PMID: 23833181
DOI: 10.1534/genetics.113.153080
PMCID: PMC3761294

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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The FACT histone chaperone guides histone H4 into its nucleosomal conformation in Saccharomyces cerevisiae.PMID 23833181Read ↗

Insight into the mechanism of nucleosome reorganization from histone mutants that suppress defects in the FACT histone chaperone.Semantic proximity Read ↗

The FACT chromatin modulator: genetic and structure/function relationships.Semantic proximity Read ↗

A nucleosomal region important for ensuring proper interactions between the transcription elongation factor Spt16 and transcribed genes in Saccharomyces cerevisiae.Semantic proximity Read ↗

Genetic interactions between POB3 and the acetylation of newly synthesized histones.Semantic proximity Read ↗

The structure of the yFACT Pob3-M domain, its interaction with the DNA replication factor RPA, and a potential role in nucleosome deposition.Semantic proximity Read ↗

The Histone Chaperone FACT Contributes to DNA Replication-Coupled Nucleosome Assembly.Semantic proximity Read ↗

FACT, the Bur kinase pathway, and the histone co-repressor HirC have overlapping nucleosome-related roles in yeast transcription elongation.Semantic proximity Read ↗

FACT and the reorganized nucleosome.Semantic proximity Read ↗

Defects in SPT16 or POB3 (yFACT) in Saccharomyces cerevisiae cause dependence on the Hir/Hpc pathway: polymerase passage may degrade chromatin structure.Semantic proximity Read ↗

New functions for an old variant: no substitute for histone H3.3.Semantic proximity Read ↗

A highly conserved region within H2B is important for FACT to act on nucleosomes.Semantic proximity Read ↗

Histone variants on the move: substrates for chromatin dynamics.Semantic proximity Read ↗

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