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Article

A general requirement for the Sin3-Rpd3 histone deacetylase complex in regulating silencing in Saccharomyces cerevisiae.

Genetics - 1 Jul 1999

Sun Z W, Hampsey M

Abstract excerpt

The Sin3-Rpd3 histone deacetylase complex, conserved between human and yeast, represses transcription when targeted by promoter-specific transcription factors. SIN3 and RPD3 also affect transcriptional silencing at the HM mating loci and at telomeres in yeast. Interestingly, however, deletion of the SIN3 and RPD3 genes enhances silencing, implying that the Sin3-Rpd3 complex functions to counteract, rather than to...

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Identifiers

PMID: 10388812
DOI: 10.1093/genetics/152.3.921
PMCID: PMC1460667

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Source receipt: pubmed, retrieved 7 Sept 2026.

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A general requirement for the Sin3-Rpd3 histone deacetylase complex in regulating silencing in Saccharomyces cerevisiae.PMID 10388812Read ↗

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