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Article

Histone deacetylase activity of Rpd3 is important for transcriptional repression in vivo.

Genes & development - 15 Mar 1998

Kadosh D, Struhl K

Abstract excerpt

Eukaryotic organisms from yeast to human contain a multiprotein complex that includes Rpd3 histone deacetylase and Sin3 corepressor. The Sin3-Rpd3 complex, when recruited to promoters by specific DNA-binding proteins, can direct transcriptional repression of specific classes of target genes. It has been proposed that the histone deacetylase activity of Rpd3 is important for repression, but direct evidence is...

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Identifiers

PMID: 9512514
DOI: 10.1101/gad.12.6.797
PMCID: PMC316629

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Histone deacetylase activity of Rpd3 is important for transcriptional repression in vivo.PMID 9512514Read ↗

A general requirement for the Sin3-Rpd3 histone deacetylase complex in regulating silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex.Semantic proximity Read ↗

Pho23 is associated with the Rpd3 histone deacetylase and is required for its normal function in regulation of gene expression and silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

Functional analysis of a RPD3 histone deacetylase homologue in Arabidopsis thaliana.Semantic proximity Read ↗

The Drosophila Sin3 gene encodes a widely distributed transcription factor essential for embryonic viability.Semantic proximity Read ↗

DSIF and RNA polymerase II CTD phosphorylation coordinate the recruitment of Rpd3S to actively transcribed genes.Semantic proximity Read ↗

Genome-wide binding map of the histone deacetylase Rpd3 in yeast.Semantic proximity Read ↗

The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and menSemantic proximity Read ↗

Structure of a Rpd3/HDAC holoenzyme complex bound to the nucleosomeSemantic proximity Read ↗

RPD1 (SIN3/UME4) is required for maximal activation and repression of diverse yeast genes.Semantic proximity Read ↗

Histone H3 lysine 36 dimethylation (H3K36me2) is sufficient to recruit the Rpd3s histone deacetylase complex and to repress spurious transcription.Semantic proximity Read ↗

Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription.Semantic proximity Read ↗

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