Article
Histone deacetylase activity of Rpd3 is important for transcriptional repression in vivo.
Genes & development - 15 Mar 1998
Kadosh D, Struhl K
Abstract excerpt
Eukaryotic organisms from yeast to human contain a multiprotein complex that includes Rpd3 histone deacetylase and Sin3 corepressor. The Sin3-Rpd3 complex, when recruited to promoters by specific DNA-binding proteins, can direct transcriptional repression of specific classes of target genes. It h...
Topics
- Acetylation
- Amino Acid Sequence
- Binding Sites
- Catalysis
- Fungal Proteins
- Gene Expression Regulation, Fungal
- Histone Deacetylases
- Molecular Sequence Data
- Mutation
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Sequence Homology, Amino Acid
- Transcription Factors
- Transcription, Genetic