Article
Structure of the SWI/SNF complex bound to the nucleosome and insights into the functional modularity
27 Apr 2021
Abstract excerpt
SWI/SNF is the prototype chromatin remodeling complex and regulates the expression of 5% genes in yeast 1 . It shows strong homology to RSC in yeast and the BAF complex in human cells. Within SWI/SNF, Snf2 functions as the ATP-dependent motor that drives the fundamental DNA translocation reaction underlying chromatin remodeling, whereas many of the auxiliary subunits target the enzyme to specific loci of the...
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