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Article

Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases.

Nature - 1 Feb 2021

Li Wanqiu, Tian Wei, Yuan Gang, Deng Pujuan, Sengupta Deepanwita, Cheng Zhongjun, Cao Yinghua, Ren Jiahao, Qin Yan, Zhou Yuqiao, Jia Yulin, Gozani Or, Patel Dinshaw J, Wang Zhanxin

Abstract excerpt

Histone methyltransferases of the nuclear receptor-binding SET domain protein (NSD) family, including NSD1, NSD2 and NSD3, have crucial roles in chromatin regulation and are implicated in oncogenesis1,2. NSD enzymes exhibit an autoinhibitory state that is relieved by binding to nucleosomes, enabling dimethylation of histone H3 at Lys36 (H3K36)3-7. However, the molecular basis that underlies this mechanism is...

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PMID: 33361816
DOI: 10.1038/s41586-020-03069-8
PMCID: PMC7889650

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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