Article
Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases.
Nature - 1 Feb 2021
Li Wanqiu, Tian Wei, Yuan Gang, Deng Pujuan, Sengupta Deepanwita, Cheng Zhongjun, Cao Yinghua, Ren Jiahao, Qin Yan, Zhou Yuqiao, Jia Yulin, Gozani Or, Patel Dinshaw J, Wang Zhanxin
Abstract excerpt
Histone methyltransferases of the nuclear receptor-binding SET domain protein (NSD) family, including NSD1, NSD2 and NSD3, have crucial roles in chromatin regulation and are implicated in oncogenesis1,2. NSD enzymes exhibit an autoinhibitory state that is relieved by binding to nucleosomes, enabl...
Topics
- Binding Sites
- Biocatalysis
- Cell Line, Tumor
- Cell Proliferation
- Cryoelectron Microscopy
- Heterografts
- Histone-Lysine N-Methyltransferase
- Histones
- Humans
- Methylation
- Models, Molecular
- Multiprotein Complexes
- Mutation
- Neoplasm Transplantation