Article

Mechanism of assembly, activation and lysine selection by the SIN3B histone deacetylase complex

2023-01-26

Abstract excerpt

Histone deacetylase complexes remove histone lysine acetylation, a key post-translational modification that activates transcription at each gene. Although these complexes are drug targets and crucial regulators of organismal physiology, their structure and mechanisms of action are largely unclear. Here, we present the first structure of a complete human SIN3B histone deacetylase holo-complex with and without a sub...

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Literature Corpus work: bca2f4b8-06de-5f74-9cad-4ce02e2da9dc
DOI: 10.1101/2023.01.26.525585

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