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Article

Structure of the human HIRA histone chaperone with a nucleosome suggests a stepwise nucleosome assembly mechanism

2026-05-18

Abstract excerpt

<h4>Summary</h4> The restoration of chromatin in the wake of a DNA or RNA polymerase is essential to maintain the integrity of eukaryotic genomes. Human HIRA is a 1.8-megadalton, three-subunit histone chaperone that mediates all replication-independent deposition of the histone variant H3.3 at active chromatin regions 1–6 . Disruption of HIRA perturbs active-chromatin organization and has wide-ranging consequenc...

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Literature Corpus work
b12321df-1b28-5e15-8dbb-3ac0daca5675
DOI
10.64898/2026.05.17.725740
Open publication

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Structure of the human HIRA histone chaperone with a nucleosome suggests a stepwise nucleosome assembly mechanismDOI 10.64898/2026.05.17.725740
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