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Bayesian genome-wide TWAS with reference transcriptomic data of brain and blood tissues identified 93 risk genes for Alzheimer’s disease dementia

2023-07-12

Abstract excerpt

<h4>Background</h4> Transcriptome-wide association study (TWAS) is an influential tool for identifying novel genes associated with complex diseases, where their genetic effects may be mediated through transcriptome. TWAS utilizes reference genetic and transcriptomic data to estimate genetic effect sizes on expression quantitative traits of target genes (i.e., effect sizes of a broad sense of expression quantitativ...

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Literature Corpus work
65afb71a-5159-5fde-911f-5e344488699a
DOI
10.1101/2023.07.06.23292336
Open publication

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Bayesian genome-wide TWAS with reference transcriptomic data of brain and blood tissues identified 93 risk genes for Alzheimer’s disease dementiaDOI 10.1101/2023.07.06.23292336
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