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Brain and Blood Transcriptome-Wide Association Studies Identify Five Novel Genes Associated with Alzheimer’s Disease

2024-04-19

Abstract excerpt

<h4>ABSTRACT</h4> <h4>INTRODUCTION</h4> Transcriptome-wide Association Studies (TWAS) extend genome-wide association studies (GWAS) by integrating genetically-regulated gene expression models. We performed the most powerful AD-TWAS to date, using summary statistics from cis -eQTL meta-analyses and the largest clinically-adjudicated Alzheimer’s Disease (AD) GWAS. <h4>METHODS</h4> We implemented the OTTERS TWAS pipe...

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Literature Corpus work
1e610bf5-3040-5ebe-b30a-284736adab79
DOI
10.1101/2024.04.17.24305737
Open publication

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Brain and Blood Transcriptome-Wide Association Studies Identify Five Novel Genes Associated with Alzheimer’s DiseaseDOI 10.1101/2024.04.17.24305737
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