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Article

Cell-type-aware transcriptome-wide association studies identify 91 independent risk genes for Alzheimer's disease dementia.

Communications biology - 22 Apr 2026

Liu Qiang, Parrish Randy L, Tang Shizhen, Tasaki Shinya, Bennett David A, Seyfried Nicholas T, De Jager Philip L, Menon Vilas, Buchman Aron S, Yang Jingjing

Abstract excerpt

Most existing transcriptome wide association studies (TWASs) of Alzheimer's Disease (AD) dementia only use bulk RNA-seq data and a single statistical method. Here, we utilize an omnibus TWAS (TWAS-O) pipeline that leverages multiple complementary statistical methods to integrate the snRNA-seq dataset (n = 415) of the dorsolateral prefrontal cortex (DLPFC) and the latest GWAS data of AD dementia. We fine-map TWAS...

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Identifiers

PMID: 42020711
DOI: 10.1038/s42003-026-10030-4
PMCID: PMC13287724

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APOE
BIN1
MAPT

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