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Article

Transcriptome-wide association analysis of Alzheimer's disease: construction and clinical validation of transcriptomic risk scores.

European archives of psychiatry and clinical neuroscience - 1 Oct 2026

Zhang Peng-Fei, Juan Zhongqian, Han Jialin, Wang Yue, Zhu Tianshu, Pang Deyun, Zheng Xin, Lu Zhiming

Abstract excerpt

Early identification of individuals at high risk for Alzheimer's disease (AD) is crucial for disease prevention and intervention. This study aims to develop AD-specific transcriptomic risk scores (TRSs) through multi-tissue transcriptome-wide association study (TWAS) and to evaluate its clinical utility in AD diagnosis and risk prediction. Using GWAS summary statistics combined with expression quantitative trait...

Read the complete abstract on PubMed

Topics

Humans
Alzheimer Disease
Female
Cognitive Dysfunction
Genome-Wide Association Study
Male

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Transcriptome

Aged

Genetic Risk Score

Genetic Predisposition to Disease

Aged, 80 and over

Source

Identifiers

PMID: 42608584
DOI: 10.1007/s00406-026-02338-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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