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Article

Multi-tissue neocortical transcriptome-wide association study implicates 8 genes across 6 genomic loci in Alzheimer's disease.

Genome medicine - 4 May 2021

Gockley Jake, Montgomery Kelsey S, Poehlman William L, Wiley Jesse C, Liu Yue, Gerasimov Ekaterina, Greenwood Anna K, Sieberts Solveig K, Wingo Aliza P, Wingo Thomas S, Mangravite Lara M, Logsdon Benjamin A

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) is an incurable neurodegenerative disease currently affecting 1.75% of the US population, with projected growth to 3.46% by 2050. Identifying common genetic variants driving differences in transcript expression that confer AD risk is necessary to elucidate AD mechanism and develop therapeutic interventions. We modify the FUSION transcriptome-wide association study (TWAS)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33947463
DOI: 10.1186/s13073-021-00890-2
PMCID: PMC8094491

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