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Article

A transcriptome-wide association study identifies novel blood-based gene biomarker candidates for Alzheimer's disease risk.

Human molecular genetics - 27 Dec 2021

Sun Yanfa, Zhou Dan, Rahman Md Rezanur, Zhu Jingjing, Ghoneim Dalia, Cox Nancy J, Beach Thomas G, Wu Chong, Gamazon Eric R, Wu Lang

Abstract excerpt

Alzheimer's disease (ad) adversely affects the health, quality of life and independence of patients. There is a critical need to identify novel blood gene biomarkers for ad risk assessment. We performed a transcriptome-wide association study to identify biomarker candidates for ad risk. We leveraged two sets of gene expression prediction models of blood developed using different reference panels and modeling...

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Identifiers

PMID: 34387340
DOI: 10.1093/hmg/ddab229
PMCID: PMC8831284

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