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Transcriptional risk scores in Alzheimer's disease: From pathology to cognition

10 Aug 2023

Abstract excerpt

INTRODUCTION: Our previously developed blood-based transcriptional risk scores (TRS) showed associations with diagnosis and neuroimaging biomarkers for Alzheimer's disease (AD). Here, we developed brain-based TRS. METHODS: We integrated AD genome-wide association study summary and expression quantitative trait locus data to prioritize target genes using Mendelian randomization. We calculated TRS using brain...

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PMID: 37563770
DOI: 10.1002/alz.13406

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