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Article

Novel Variance-Component TWAS method for studying complex human diseases with applications to Alzheimer’s dementia

2020-05-29

Abstract excerpt

Transcriptome-wide association studies (TWAS) have been widely used to integrate transcriptomic and genetic data to study complex human diseases. Within a test dataset lacking transcriptomic data, existing TWAS methods first impute gene expression by creating a weighted sum that aggregates SNPs with their corresponding cis-eQTL effects on reference transcriptome. Existing TWAS methods then employ a linear regressi...

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Literature Corpus work
a512ae83-8ff0-56f9-bcbe-fecb917c3486
DOI
10.1101/2020.05.26.117515
Open publication

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Novel Variance-Component TWAS method for studying complex human diseases with applications to Alzheimer’s dementiaDOI 10.1101/2020.05.26.117515
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