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Article

Brain and blood transcriptome-wide association studies identify five novel genes associated with Alzheimer's disease.

Journal of Alzheimer's disease : JAD - 1 May 2025

Mews Makaela A, Naj Adam C, Griswold Anthony J, Below Jennifer E, Bush William S

Abstract excerpt

BackgroundGenome-wide association studies (GWAS) have identified numerous genetic variants associated with Alzheimer's disease (AD), but their functional implications remain unclear. Transcriptome-wide association studies (TWAS) offer enhanced statistical power by analyzing genetic associations at the gene level rather than at the variant level, enabling assessment of how genetically-regulated gene expression...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40111921
DOI: 10.1177/13872877251326288
PMCID: PMC13066465

Genes

CYB561
MADD
MTCH2
MYBPC3
ZNF439
ANXA11
LYSMD4
PRKAG1
PSMA5
SLC11A2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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