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Article

Bayesian genome-wide TWAS with reference transcriptomic data of brain and blood tissues identified 141 risk genes for Alzheimer's disease dementia.

Alzheimer's research & therapy - 1 Jun 2024

Guo Shuyi, Yang Jingjing

Abstract excerpt

BACKGROUND: Transcriptome-wide association study (TWAS) is an influential tool for identifying genes associated with complex diseases whose genetic effects are likely mediated through transcriptome. TWAS utilizes reference genetic and transcriptomic data to estimate effect sizes of genetic variants on gene expression (i.e., effect sizes of a broad sense of expression quantitative trait loci, eQTL). These...

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PMID: 38824563
DOI: 10.1186/s13195-024-01488-7
PMCID: PMC11144322

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