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Article

A transcriptome-wide association study of Alzheimer's disease using prediction models of relevant tissues identifies novel candidate susceptibility genes.

Genome medicine - 1 Sept 2021

Sun Yanfa, Zhu Jingjing, Zhou Dan, Canchi Saranya, Wu Chong, Cox Nancy J, Rissman Robert A, Gamazon Eric R, Wu Lang

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWAS) have identified over 56 susceptibility loci associated with Alzheimer's disease (AD), but the genes responsible for these associations remain largely unknown. METHODS: We performed a large transcriptome-wide association study (TWAS) leveraging modified UTMOST (Unified Test for MOlecular SignaTures) prediction models of ten brain tissues that are potentially...

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Identifiers

PMID: 34470669
DOI: 10.1186/s13073-021-00959-y
PMCID: PMC8408990

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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