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Article

Novel Variance-Component TWAS method for studying complex human diseases with applications to Alzheimer's dementia.

PLoS genetics - 1 Apr 2021

Tang Shizhen, Buchman Aron S, De Jager Philip L, Bennett David A, Epstein Michael P, Yang Jingjing

Abstract excerpt

Transcriptome-wide association studies (TWAS) have been widely used to integrate transcriptomic and genetic data to study complex human diseases. Within a test dataset lacking transcriptomic data, traditional two-stage TWAS methods first impute gene expression by creating a weighted sum that aggregates SNPs with their corresponding cis-eQTL effects on reference transcriptome. Traditional TWAS methods then employ...

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Identifiers

PMID: 33798195
DOI: 10.1371/journal.pgen.1009482
PMCID: PMC8046351

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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