Article

The human inactive X chromosome modulates expression of the active X chromosome

2021-08-09

Abstract excerpt

<h4>Summary</h4> Researchers have presumed that the “inactive” X chromosome (Xi) has little impact, in trans, on the “active” X (Xa). To test this, we quantified Xi and Xa gene expression in individuals with one Xa and zero to three Xi’s. Our linear modeling revealed modular Xi and Xa transcriptomes and significant Xi-driven expression changes for 38% (162/423) of expressed X-chromosome genes. By integrating alle...

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Literature Corpus work: 64964d86-1090-53e8-aa29-b754e85580ac
DOI: 10.1101/2021.08.09.455676

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