Analysis of expressed SNPs identifies variable extents of expression from the human inactive X chromosome.

doi:10.1186/gb-2013-14-11-r122

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Article

Analysis of expressed SNPs identifies variable extents of expression from the human inactive X chromosome.

Genome biology - 1 Nov 2013

Cotton Allison M, Ge Bing, Light Nicholas, Adoue Veronique, Pastinen Tomi, Brown Carolyn J

Abstract excerpt

BACKGROUND: X-chromosome inactivation (XCI) results in the silencing of most genes on one X chromosome, yielding mono-allelic expression in individual cells. However, random XCI results in expression of both alleles in most females. Allelic imbalances have been used genome-wide to detect mono-allelically expressed genes. Analysis of X-linked allelic imbalance in females with skewed XCI offers the opportunity to...

Topics

Alleles
Chromosomes, Human, X
Female
Gene Expression Regulation
Genes, X-Linked
Humans
Multigene Family
Polymorphism, Single Nucleotide
X Chromosome Inactivation

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Identifiers

PMID: 24176135
DOI: 10.1186/gb-2013-14-11-r122
PMCID: PMC4053723

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