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Stable and robust Xi and Y transcriptomes drive cell-type-specific autosomal and Xa responses in vivo and in vitro in four human cell types

2024-03-19

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<h4>Summary</h4> Recent in vitro studies of human sex chromosome aneuploidy showed that the Xi (“inactive” X) and Y chromosomes broadly modulate autosomal and Xa (“active” X) gene expression in two cell types. We tested these findings in vivo in two additional cell types. Using linear modeling in CD4+ T cells and monocytes from individuals with one to three X chromosomes and zero to two Y chromosomes, we identi...

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Literature Corpus work: 11cf1f51-2c17-5db4-85fb-596ac861547e
DOI: 10.1101/2024.03.18.585578

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Stable and robust Xi and Y transcriptomes drive cell-type-specific autosomal and Xa responses <i>in vivo</i> and <i>in vitro</i> in four human cell types

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