Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

X-factors in human disease: impact of gene content and dosage regulation.

Human molecular genetics - 1 Oct 2021

Fang He, Deng Xinxian, Disteche Christine M

Abstract excerpt

The gene content of the X and Y chromosomes has dramatically diverged during evolution. The ensuing dosage imbalance within the genome of males and females has led to unique chromosome-wide regulatory mechanisms with significant and sex-specific impacts on X-linked gene expression. X inactivation or silencing of most genes on one X chromosome chosen at random in females profoundly affects the manifestation of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aneuploidy
Share to Chromosomes, Human, X
Share to Gene Dosage

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Genes, X-Linked

Share to Genetic Association Studies

Share to Organ Specificity

Share to X Chromosome Inactivation

Source

Open in PubMed Open full text

Identifiers

PMID: 34387327
DOI: 10.1093/hmg/ddab221
PMCID: PMC8490017

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

X-factors in human disease: impact of gene content and dosage regulation.PMID 34387327Read ↗

X-chromosome inactivation and its implications for human diseaseSemantic proximity Read ↗

X-chromosome inactivation: molecular mechanisms from the human perspective.Semantic proximity Read ↗

A whole-organism landscape of X-inactivation in humansSemantic proximity Read ↗

X-chromosome inactivation: molecular mechanisms and genetic consequences.Semantic proximity Read ↗

X-Chromosome Inactivation and Related DiseasesSemantic proximity Read ↗

Landscape of X chromosome inactivation across human tissues.Semantic proximity Read ↗

Landscape of X chromosome inactivation across human tissuesSemantic proximity Read ↗

Heritability of skewed X-inactivation in female twins is tissue-specific and dependent on ageSemantic proximity Read ↗

Escape from X inactivation varies across genes and tissues and shapes sex-biased sex chromosome gene expressionSemantic proximity Read ↗

X-inactivation profile reveals extensive variability in X-linked gene expression in females.Semantic proximity Read ↗

Skewed X inactivation in X-linked disorders.Semantic proximity Read ↗

The human Y and inactive X chromosomes similarly modulate autosomal gene expressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.