X-factors in human disease: impact of gene content and dosage regulation.

doi:10.1093/hmg/ddab221

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Article

X-factors in human disease: impact of gene content and dosage regulation.

Human molecular genetics - 1 Oct 2021

Fang He, Deng Xinxian, Disteche Christine M

Abstract excerpt

The gene content of the X and Y chromosomes has dramatically diverged during evolution. The ensuing dosage imbalance within the genome of males and females has led to unique chromosome-wide regulatory mechanisms with significant and sex-specific impacts on X-linked gene expression. X inactivation or silencing of most genes on one X chromosome chosen at random in females profoundly affects the manifestation of...

Topics

Alleles
Aneuploidy
Chromosomes, Human, X
Female
Gene Dosage
Gene Expression Regulation
Genes, X-Linked
Genetic Association Studies
Genetic Predisposition to Disease
Humans
Male
Organ Specificity
X Chromosome Inactivation

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Identifiers

PMID: 34387327
DOI: 10.1093/hmg/ddab221
PMCID: PMC8490017

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