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Article

Random allelic expression in the adult human body.

Cell reports - 31 Jan 2023

Kravitz Stephanie N, Ferris Elliott, Love Michael I, Thomas Alun, Quinlan Aaron R, Gregg Christopher

Abstract excerpt

Genes are typically assumed to express both parental alleles similarly, yet cell lines show random allelic expression (RAE) for many autosomal genes that could shape genetic effects. Thus, understanding RAE in human tissues could improve our understanding of phenotypic variation. Here, we develop a methodology to perform genome-wide profiling of RAE and biallelic expression in GTEx datasets for 832 people and 54...

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PMID: 36640362
DOI: 10.1016/j.celrep.2022.111945
PMCID: PMC10484211

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