Article

Genetic Basis, Quantitative Nature, and Functional Relevance of Evolutionarily Conserved DNA Methylation

2024-11-09

Abstract excerpt

DNA methylation (DNAm) is a key epigenetic mark that modulates regulatory elements and gene expression, playing a crucial role in mammalian development and physiological function. Despite extensive characterization of DNAm profiles across species, little is known about its evolutionary conservation. Here, we conducted a comparative epigenome-wide analysis of great apes to identify and characterize sequence- and me...

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Literature Corpus work: f76721eb-8d6d-5bde-bb36-71526c268995
DOI: 10.1101/2024.11.07.622474

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