Article

Whole-genome profiling of native 5-hydroxymethylation in human neurons with long-read sequencing

2026-01-12

Abstract excerpt

The 5-hydroxymethylcytosine (5hmC) modification of DNA is particularly prevalent in neurons and thereby a hallmark of the brain’s epigenetic landscape. While 5mC DNA methylation is a well-known player in genome stability and transcriptional regulation, the role of 5hmC remains largely unknown. Here, we used long-read Oxford Nanopore Technology (ONT) to profile whole-genome, native 5mC and 5hmC levels in sorted neu...

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Literature Corpus work: 39bb8501-a83d-5f6e-aaa9-b10642fdb094
DOI: 10.64898/2026.01.11.695537

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