Article

Epigenomic complexity of the human brain revealed by single-cell DNA methylomes and 3D genome structures

2022-12-01

Abstract excerpt

Delineating the gene regulatory programs underlying complex cell types is fundamental for understanding brain functions in health and disease. Here, we comprehensively examine human brain cell epigenomes by probing DNA methylation and chromatin conformation at single-cell resolution in over 500,000 cells from 46 brain regions. We identified 188 cell types and characterized their molecular signatures. Integrative a...

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Literature Corpus work: 11a6540a-1787-5e01-8450-2db848308cd5
DOI: 10.1101/2022.11.30.518285

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