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Article

Identification of the elementary structural units of the DNA damage response

12 Jun 2017

Abstract excerpt

Histone H2AX phosphorylation is an early signalling event triggered by DNA double-strand breaks (DSBs). To elucidate the elementary units of phospho-H2AX-labelled chromatin, we integrate super-resolution microscopy of phospho-H2AX during DNA repair in human cells with genome-wide sequencing analyses. Here we identify phospho-H2AX chromatin domains in the nanometre range with median length of ∼75 kb. Correlation...

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PMID: 28604675
DOI: 10.1038/ncomms15760

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